Posted on Mar 31, 2011
Some possibly good news for victims of traumatic brain injury.  Edge Therapeutics announced at the American Stroke Associations International Conference in March a developmental treatment for TBI that could prevent delayed complications of sudden and traumatic brain injury.  Being called NimoGel, the treatment is described as an investigational sustained-release medicine delivered directly to the brain. Clinical trials have shown it may be able to prevent delayed complications of severe and/or traumatic brain injuries.

The news was announced at the American Stroke Association's International Stroke Conference earlier this month. Research suggests that NimoGel effectively prevented cerebral vasospasm, which is the constriction of blood vessels in the brain, after subarachnoid hemorrhage (SAH). Cerebral vasospasm is a leading cause of permanent brain damage and death after brain injury.

"There is a tremendous unmet medical need in treating brain injuries. Treatments available today are only minimally effective in part because the systemically administered doses that can be tolerated by patients are too low to prevent certain types of delayed complications such as cerebral vasospasm," said R. Loch Macdonald, MD, PhD, Keenan Endowed Chair and Head of the Division of Neurosurgery at St. Michael's Hospital, University of Toronto and Chief Scientific Officer of Edge Therapeutics.

"This preclinical study suggests that it is possible to achieve adequate and sustained concentrations of nimodipine locally and prevent cerebral vasospasm and other potentially deadly complications after brain injury. Based on these encouraging results in a large animal model, further evaluation of NimoGel in human clinical trials is warranted."

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James Roswold is a Kansas & Missouri personal injury, workers comp, and medical malpractice attorney.